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KMID : 1151820160100030195
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Journal of the Korean Society of Radiology
2016 Volume.10 No. 3 p.195 ~ p.200
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The Apoptosis according to the Processing Irradiation and The Tumor Necrosis Factor
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Lee Jae-Sub
Jang Seong-Joo
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Abstract
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Acute promyelocytic leukemia(APL) is not just the poor grades of treating a type of blood cancer hayeoteul combination with chemotherapy despite concurrent radiation therapy are known to exhibit a greater effect and also works on normal cells to result in side effects. In this study, when after treatment with gamma rays, such as TNF-α in order to reduce these side effects was confirmed how affected the cell death of normal cells and cancer cells. HL-60 cells were used as the APL cell line HL-60 cells were differentiated with DMSO for treatment are shown the properties of normal granulocytes was used as a control group. As a result, HL-60 cells treated with TNF-α and gamma rays with only showed a cytotoxic effect by inducing the apoptosis cells were put to death. Consequently, TNF-α is thought to active substances that can increase the efficiency of cancer treatment to increase the removal of cancer cells when used with low-density gamma-ray treatment in order to eliminate the side effects of chemotherapy.
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KEYWORD
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Acute promyelocytic leukemia, gamma ray, Tumor Necrosis Factor, Apoptosis
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